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Evaluation of potential use in arthritis by producing a chronic inflammatory condition by administration of Freund' s adjuvant. Rat adjuvant arthritis ( AIA) is an experimental model of polyarthritis that has been widely used for preclinical testing of numerous anti- arthritic agents, which are either under preclinical or clinical investigation, or are currently used as therapeutics in this disease 2- 4. Adjuvant arthritis was induced on day 0 of the experiment by a single subcutaneous injection of 200 μL of CFA ( complete Freund adjuvant) into the plantar surface of right hind paw of the mice with a 25- gauge hypodermic needle ( Lao et al. Disorders of ASIA include arthritis, type 1 diabetes, multiple sclerosis, macrophagic myofasciitis, and Gulf War syndrome. The inflammation, manifesting as redness, edema, and hyper- responsiveness to noxious stimuli, was limited to the injected paw. By Yong- qiu Zheng, Wei Wei, Yu- xian Shen, Min Dai and Li- hua LiuYong- qiu Zheng, Wei Wei, Yu- xian Shen, Min Dai and Li- hua Liu.
The word " adjuvant" comes from the Latin word adiuvare, meaning to help or aid. This arthritis model, called Adjuvant- Induced Arthritis ( AIA), has previously been used as a model for rheumatoid arthritis ( RA). Adjuvant Arthritis.
Adjuvant arthritis, induced by injections of Freund' s complete adjuvant into the footpads of some rat strains, has been recognized as a useful animal model for many years. In adults, long term persistence of aluminum is known to lead to mental decline, as in Alzheimer’ s disease, and autoimmune disorders. It has recently been suggested ( 1, 2) that adjuvant arthrit is may present a condit ion of chronic pain in the rat. " An immunologic adjuvant is defined as any substance that acts to accelerate, prolong, or enhance antigen- specific immune responses when used in combination with specific vaccine antigens.
Adjuvant arthritis: immunopathological and hyperalgesic features. Adjuvant arthritis is an experimental immunopathy that is thought to share many features of human rheumatoid arthritis and, as such, is one of the most widely used models for studying the anti- inflammatory properties of compounds. Adjuvans arthritis ist. Rosenthale ME, Capetola RJ. Auch die Adjuvans- Arthritis ist wie die rheumatoide Arthritis ( primär chronische Polyarthritis ( pcP) ) des Menschen eine Allgemeinerkrankung und sollte daher richtiger als Adjuvans- Krankheit.
There has, however, been notable lack of success in reproducing this model in other species. The results are consistent with the hypothesis that arthrit ic rats hypervent i late and contr ibute to the val idat ion of adjuvant arthrit is as an animal model of chronic pain. The lesions in adjuvant arthritis are somewhat less analogous to those seen in human RA than are the lesions of type II. However, AIA is a more appropriate model for reactive arthritis rather than RA, due to the apparent differences in histological and immunological features between the two. Adjuvant arthritis or streptococcal cell wall arthritis are dependent on the activation of the innate immune system by TLR ligands. Auch die Adjuvans- Arthritis ist wie die rheumatoide Arthritis ( primär chronische Polyarthritis ( pcP) ) des Menschen eine Allgemeinerkrankung und sollte daher.